Title : Role of N - terminal amino acids in the absorption - enhancing effects of the C - terminal fragment of Clostridium Perfringens enterotoxin
نویسندگان
چکیده
Department of Pharmaceutics and Biopharmaceutics, Showa Pharmaceutical University (A.M., M.K., H.S., A.T., M.H., M.F., Y.W.), Machida, Tokyo 194-8543, Japan. Project III, National Institute of Biomedical Innovation (H.M.), Osaka 567-0085, Japan. Department of Bacterial Toxinology, Research Institute for Microbial Diseases, Osaka University (Y.H.), Osaka 565-0871, Japan. JPET Fast Forward. Published on May 3, 2005 as DOI:10.1124/jpet.105.085399
منابع مشابه
Role of N-terminal amino acids in the absorption-enhancing effects of the c-terminal fragment of Clostridium perfringens enterotoxin.
We recently found that a polypeptide, the C-terminal of Clostridium perfringens enterotoxin (C-CPE), was a novel type of drug absorption enhancer. The C-terminal of C-CPE is thought to play a role in the binding of C-CPE to its receptor, claudin-4; however, the function of the N-terminal of C-CPE is unclear. In the present study, we evaluated the role of the N-terminal domain of C-CPE in jejuna...
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