Economic Analysis Of Evarrest® Sealant Matrix Compared With Standard Of Care In Severe Soft Tissue Surgical Bleeding: A United Kingdom Hospital Perspective.

unheated CO2 (U-CO2) in laparoscopic patients. Efficacy data were derived from a published randomised controlled trial reporting on the proportion of patients with hypothermia, a US database analysis of hypothermia patients for open surgery, and from an unpublished UK NHS before and after study of laparoscopic surgery patients. Other parameter inputs were obtained from published literature. Deterministic and probabilistic sensitivity analyses were conducted to assess the robustness of results. Scenario analyses were undertaken to explore structural uncertainty within the model. Results: The use of WH-CO2 dominated standard care, as it was both cost saving and generated greater QALYs, for both open and laparoscopic surgery patients over a one year time horizon. Results varied by the number of patients undergoing surgery per humidifier per year. Based on 250 patients using the humidifier each year over a five year lifetime of the humidifier, WH-CO2 dominated no insufflation in open surgery patients in 71% of model iterations and dominated U-CO2 in laparoscopic surgery in 98% of model iterations. WH-CO2 remained the cost-effective treatment option at a willingness-to-pay threshold of £20,000 per QALY throughout all scenario and sensitivity analyses considered, provided 10 or more patients used each humidifier over its life span. ConClusions: The analyses conducted suggest that based upon the currently available clinical evidence, WH-CO2 is a cost-effective use of resources for patients undergoing either open or laparoscopic colorectal surgery within the UK NHS.