11-Keto-9(E),12(E)-octadecadienoic acid, a novel fatty acid that enhances fibrinolytic activity of endothelial cells.

the regulation of fibrinolysis in the blood vessel by producing plasminogen activators and plasminogen activator inhibitors. Defects in physiological regulation of the balance of the activities between plasminogen activator and the inhibitors may cause vascular diseases such as thromboembolismand atherosclerosis. In patients with such diseases, the inhibitor may be dominant in this balance. Actually, the expression of plasminogen activator inhibitor-1 is increased in atherosclerotic arteries1~3), and elevated levels of the inhibitor are