Hyporeactivity of Infection: Potential Limitation
نویسندگان
چکیده
Interferon inducers are generally most effective as antiviral agents when used prophylactically. One possible explanation for this is that animals develop a state of hyporeactivity during the course of a virus infection. Such a progressive loss of capacity to produce interferon was observed with a representative group of interferon-inducing agents (polyinosinic-cytidylic acid, Tilorone hydrochloride, Newcastle disease virus, or a strain of encephalomyocarditis virus) during the course of a model picornavirus infection in mice.
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