A novel vanilloid receptor-1 (VR-1) variant mammalian salt taste receptor.
نویسندگان
چکیده
An amiloride-insensitive (AI) salt taste receptor is the predominant transducer of Na+ taste in some mammalian species. Accordingly, the objective of this study was to characterize the AI-salt taste receptor. The AI-salt taste receptor in rat and mouse fungiform taste receptor cells (TRCs) was activated by the vanilloid receptor-1 (VR-1) agonists, resiniferatoxin (RTX), capsiacin (CAP) and elevated temperature (>38°), and was inhibited by the VR-1 antagonist, SB-366791 (Lyall et al., 2004). VR-1 knockout mice demonstrated no functional AI-salt taste receptor and no salt sensitivity to vanilloids and temperature. We conclude that the AI-salt taste receptor is derived from the VR-1 gene.
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ورودعنوان ژورنال:
- Chemical senses
دوره 30 Suppl 1 شماره
صفحات -
تاریخ انتشار 2005