HLA-G in Amerindians: Epidemiology and Worldwide Population Comparison
نویسندگان
چکیده
Received: November 9, 2017 Revised: December 23, 2017 Accepted: December 27, 2017 Abstract: Background: HLA-G molecules are immunosuppressive and avoid fetal rejection by giving negative signals to maternal immune system from fetal trophoblast cell surface. HLA-G genes have been associated to different pathologies: Spontaneous abortions, autoimmunity, tumor progression, transplant rejection and infection. In addition, different World populations show remarkable different HLA-G allele frequencies in the allele that does not produce a full HLA-G molecule (HLA-G*05N); this allele is almost absent in studied Amerindians.
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