Brain arousal regulation as response predictor for antidepressant therapy in major depression

نویسندگان

  • Frank M. Schmidt
  • Christian Sander
  • Marie-Elisa Dietz
  • Claudia Nowak
  • Thomas Schröder
  • Roland Mergl
  • Peter Schönknecht
  • Hubertus Himmerich
  • Ulrich Hegerl
چکیده

A tonically high level of brain arousal and its hyperstable regulation is supposed to be a pathogenic factor in major depression. Preclinical studies indicate that most antidepressants may counteract this dysregulation. Therefore, it was hypothesized that responders to antidepressants show a) a high level of EEG-vigilance (an indicator of brain arousal) and b) a more stable EEG-vigilance regulation than non-responders. In 65 unmedicated depressed patients 15-min resting-state EEGs were recorded off medication (baseline). In 57 patients an additional EEG was recorded 14 ± 1 days following onset of antidepressant treatment (T1). Response was defined as a ≥50% HAMD-17-improvement after 28 ± 1 days of treatment (T2), resulting in 29 responders and 36 non-responders. Brain arousal was assessed using the Vigilance Algorithm Leipzig (VIGALL 2.1). At baseline responders and non-responders differed in distribution of overall EEG-vigilance stages (F2,133 = 4.780, p = 0.009), with responders showing significantly more high vigilance stage A and less low vigilance stage B. The 15-minutes Time-course of EEG-vigilance did not differ significantly between groups. Exploratory analyses revealed that responders showed a stronger decline in EEG-vigilance levels from baseline to T1 than non-responders (F2,130 = 4.978, p = 0.005). Higher brain arousal level in responders to antidepressants supports the concept that dysregulation of brain arousal is a possible predictor of treatment response in affective disorders.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Efficacy of Pharmacotherapy and Cognitive Therapy, Alone and in Combination in Major Depressive Disorder

Introduction & Objective: Patients with Major depressive are difficult to treat, and the relative efficacy of medications and cognitive therapy in the treatment of depression is still a matter of deabath. The purpose of this study was to compare the efficacies of antidepressant medication, cognitive therapy and combination of cognitive therapy and antidepressant medication. Materials & Met...

متن کامل

Inflammation and Immune Regulation as Potential Drug Targets in Antidepressant Treatment

Growing evidence supports a mutual relationship between inflammation and major depression. A variety of mechanisms are outlined, indicating how inflammation may be involved in the pathogenesis, course and treatment of major depression. In particular, this review addresses 1) inflammatory cytokines as markers of depression and potential predictors of treatment response, 2) findings that cytokine...

متن کامل

Treatment of Depression in the Elderly: A Systematic Review

Depression is a common symptom and a major public health problem in the elderly. Despite its prevalence and seriousness, depressive disorder in older people remains under-treated. The optimal treatment of depression in later life is crucial, and requires appreciation of several age-related factors such as comorbidity, polypharmacy, altered drug kinetics, variable treatment response and increase...

متن کامل

The Efficacy of Emotion Regulation Therapy in Attention Control, Mindfulness and Reappraisal of Patients with Generalized Anxiety Disorder Comorbid with Major Depression

Introduction: Various studies indicate that generalized anxiety disorder has a high comorbidity with major depression disorder. Emotion dysregulation plays an important role in onset and maintenance of generalized anxiety disorder and major depressive disorder. The purpose of this study was to examine the efficacy of emotion regulation therapy in control of attention, mindfulness and reappraisa...

متن کامل

The Effectiveness of Emotional Schema Therapy on Severity of Depression and Cognitive Emotional Regulation Strategies in Major Depression Disorder

Introduction: Major Depression disorder is the most common psychiatric disorder in which mood swings and sadness are prominent symptoms. This study aimed to evaluate the effectiveness of emotional schema therapy on the severity of depression and cognitive emotion regulation strategies. Method: The present study was a pre-test, post-test design with a control group. Among the patients with major...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره 7  شماره 

صفحات  -

تاریخ انتشار 2017