Mathematically modeling the sequential application of a cytotoxic nanoparticle and a PI3K-inhibitor enhances anti-tumor efficacy

Ambarish Pandey , Ashish Kulkarni, Bhaskar Roy, Aaron Goldman, Sasmit Sarangi, Poulomi Sengupta, Colin Phipps, Jawahar Kopparam, Michael Oh, Sudipta Basu, Mohammad Kohandel, Shiladitya Sengupta. Laboratory for Nanomedicine, Division of Biomedical Engineering, Brigham and Women’s Hospital, Department of Medicine, Harvard Medical School. Department of Applied Mathematics, University of Waterloo, Waterloo, ON, N2L 3G1, Canada. Waterloo Institute for Nanotechnology, University of Waterloo, Waterloo, ON, N2L 3G1, Canada. Center for Mathematical Medicine, Fields Institute for Research in Mathematical Sciences, Toronto, ON, M5T 3J1, Canada. Current Affiliation: Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas.