Author's response to reviews Title: Limitations in high-throughput drug screening on a cellular model for Friedreich ataxia Authors:
نویسندگان
چکیده
Nadège Calmels ([email protected]) Hervé Seznec ([email protected]) Pascal Villa ([email protected]) Laurence Reutenauer ([email protected]) Marcel Hibert ([email protected]) Jacques Haiech ([email protected]) Pierre Rustin ([email protected]) Michel Koenig ([email protected]) Hélène Puccio ([email protected])
منابع مشابه
Limitations in a frataxin knockdown cell model for Friedreich ataxia in a high-throughput drug screen
BACKGROUND Pharmacological high-throughput screening (HTS) represents a powerful strategy for drug discovery in genetic diseases, particularly when the full spectrum of pathological dysfunctions remains unclear, such as in Friedreich ataxia (FRDA). FRDA, the most common recessive ataxia, results from a generalized deficiency of mitochondrial and cytosolic iron-sulfur cluster (ISC) proteins acti...
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The principle of this method was to screen the pharmacological activity of six prepared polyphyto formulations by using high throughput screening method for their nootropic action. The study was performed in three stages using one, two and three animals, respectively in a group. Test formulations were given p.o daily at the dose of 50 and 100 mg/kg body weight. The test formulations were compar...
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Wahiba Hamza ([email protected]) Lamia Ali Pacha ([email protected]) Tarik Hamadouche ([email protected]) Jean Müller ([email protected]) Nathalie Drouot ([email protected]) Farida Ferrat ([email protected]) Samira Makri ([email protected]) Malika Chaouch ([email protected]) Meriem Tazir ([email protected]) Michel Koenig ([email protected]) Traki Benhassine ...
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