Impact of diet and stress on the development of preeclampsia-like symptoms in p57 mice
نویسندگان
چکیده
Stéphanie Falcao, Crina Solomon, Caroline Monat, Julie Bérubé, Jolanta Gutkowska, and Julie L. Lavoie Research Centre, Centre Hospitalier de l’Université de Montréal-Technopôle Angus, Montréal, Department of Biomedical Sciences, Université de Montréal, Montréal, Research Centre, Centre hospitalier de l’Université de Montréal-Hôtel-Dieu, Montréal, and Department of Medicine, Université de Montréal, Montréal, Québec, Canada
منابع مشابه
Impact of diet and stress on the development of preeclampsia-like symptoms in p57kip2 mice.
The cyclin-dependent kinase inhibitor p57(kip2) regulates the cell cycle of trophoblastic cells. It has been established by a Japanese group that the heterozygous p57(kip2) knockout (p57(-/+)) mice are a good model of preeclampsia as they develop hypertension, proteinuria, and placental pathology. However, apart from the placental pathology, we could not observe these symptoms in our laboratory...
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p57Kip2, a potent inhibitor of several cyclin/cyclin dependent kinase complexes (CDK ), is a paternally imprinted gene in both humans and mice, and here we show that pregnant mice which are heterozygous for p57Kip2 deficiency display symptoms similar to preeclampsia. p57-/+ (heterozygotes for p57Kip2 ) female mice that were mated with p57-/+ males showed hypertension, proteinuria, thrombocytope...
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