Studies on the mechanism of action of dioctyl sodium sulphosuccinate in the human jejunum.
نویسندگان
چکیده
An intestinal perfusion technique has been used to investigate the mechanism of action of the laxative, dioctyl sodium sulphosuccinate, in the human jejunum. Dioctyl sodium sulphosuccinate stimulated net secretion of water, sodium, chloride and potassium and inhibited net absorption of glucose and bicarbonate. These changes in water and solute transport were partially reversed by administration of indomethacin (4 mg/kg/day orally for three days), which suggests that they are mediated in part by endogenous prostaglandins.
منابع مشابه
Increased cell loss in the human jejunum induced by laxatives (ricinoleic acid, dioctyl sodium sulphosuccinate, magnesium sulphate, bile salts).
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ورودعنوان ژورنال:
- Gut
دوره 26 10 شماره
صفحات -
تاریخ انتشار 1985