Regulation of the UNC-18-Caenorhabditis elegans syntaxin complex by UNC-13.
نویسندگان
چکیده
The Caenorhabditis elegans unc-13, unc-18, and unc-64 genes are required for normal synaptic transmission. The UNC-18 protein binds to the unc-64 gene product C. elegans syntaxin (Ce syntaxin). However, it is not clear how this protein complex is regulated. We show that UNC-13 transiently interacts with the UNC-18-Ce syntaxin complex, resulting in rapid displacement of UNC-18 from the complex. Genetic and biochemical evidence is presented that UNC-13 contributes to the modulation of the interaction between UNC-18 and Ce syntaxin.
منابع مشابه
Direct interaction of the rat unc-13 homologue Munc13-1 with the N terminus of syntaxin.
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ورودعنوان ژورنال:
- The Journal of neuroscience : the official journal of the Society for Neuroscience
دوره 19 12 شماره
صفحات -
تاریخ انتشار 1999