Control of cardiac pyruvate dehydrogenase activity in peroxisome proliferator-activated receptor- transgenic mice
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چکیده
Teresa A. Hopkins,1 Mary C. Sugden,2 Mark J. Holness,2 Ray Kozak,1 Jason R. B. Dyck,1 and Gary D. Lopaschuk1 1Departments of Pharmacology and Pediatrics, University of Alberta, Edmonton, Alberta, Canada T6G 2S2; and 2Division of General and Developmental Medicine, Department of Diabetes and Metabolic Medicine, St. Bartholomew’s and the Royal London School of Medicine and Dentistry, Queen Mary, University of London, London, E1 4NS United Kingdom
منابع مشابه
Control of cardiac pyruvate dehydrogenase activity in peroxisome proliferator-activated receptor-alpha transgenic mice.
The pyruvate dehydrogenase enzyme complex (PDC) is rate limiting for glucose oxidation in the heart. Inhibition of PDC by end-product feedback and phosphorylation by pyruvate dehydrogenase kinase (PDK) operate in concert to inhibit PDC activity. Because the transcriptional regulator peroxisome proliferator-activated receptor (PPAR)-alpha increases PDK expression in some tissues, we examined wha...
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تاریخ انتشار 2003