Ovarian carcinomas and borderline ovarian tumors - molecular markers and operative treatment
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بررسی نسبت LH و FSH سرم به مایع کیست تخمدان در تودههای تخمدانی
Abstract Backgraound: Regarding the prevalence and high mortality rate of ovarian cancers, importance of markers to determine ovarian malignancies earlier, considerable experimental evidence about serum Gonadotropins to cyst fluid ratio with pathology of ovarian tumors and finally not enough experiments in our country, the present study was performed in Imam Hossein hospital between 2008 and...
متن کاملCorrection: Genomic Classification of Serous Ovarian Cancer with Adjacent Borderline Differentiates RAS Pathway and TP53-Mutant Tumors and Identifies NRAS as an Oncogenic Driver.
PURPOSE Low-grade serous ovarian carcinomas (LGSC) are Ras pathway-mutated, TP53 wild-type, and frequently associated with borderline tumors. Patients with LGSCs respond poorly to platinum-based chemotherapy and may benefit from pathway-targeted agents. High-grade serous carcinomas (HGSC) are TP53-mutated and are thought to be rarely associated with borderline tumors. We sought to determine whe...
متن کاملAn Outlook on Ovarian Cancer and Borderline Ovarian Tumors: Focus on Genomic and Proteomic Findings
Among the gynaecological malignancies, ovarian cancer is one of the neoplastic forms with the poorest prognosis and with the bad overall and disease-free survival rates than other gynaecological cancers. Ovarian tumors can be classified on the basis of the cells of origin in epithelial, stromal and germ cell tumors. Epithelial ovarian tumors display great histological heterogeneity and can be f...
متن کاملBiology of Human Tumors Genomic Classification of Serous Ovarian Cancer with Adjacent Borderline Differentiates RAS Pathway and TP53- Mutant Tumors and Identifies NRAS as an Oncogenic Driver
Purpose: Low-grade serous ovarian carcinomas (LGSC) are Ras pathway-mutated, TP53 wild-type, and frequently associated with borderline tumors. Patients with LGSCs respond poorly to platinumbased chemotherapy and may benefit from pathway-targeted agents. High-grade serous carcinomas (HGSC) are TP53-mutated and are thought to be rarely associated with borderline tumors. We sought to determine whe...
متن کاملCommentary (Trimble/Trimble): Update on Low Malignant Potential Ovarian Tumors
Nomenclature Various names have been applied to this entity. These include “ovarian tumors of low malignant potential,” “borderline ovarian tumors,” “atypical proliferating ovarian tumors,” and even “borderline ovarian carcinomas.” Each of these terms has its drawbacks. “Low malignant potential” suggests that these tumors have a certain propensity to become malignant. In fact, as Kurman and Tri...
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