Cholestasis due to D-penicillamine toxicity.
نویسندگان
چکیده
A patient with sero-positive rheumatoid arthritis was treated with D-penicillamine (cumulative dose 3 . 7 3 9 . Three weeks after starting therapy she developed a fever, rash and a cholestatic jaundice. Cessation of D-penicillamine resulted in improvement. However, reintroduction of D-penicillamine 1 0 days later (cumulative dose 2g), was followed by acute hepatic failure and death. Liver biopsy showed widespread centrizonal necrosis and cholestasis. This case represents a hypersensitivity reaction t o D-penicillamine.
منابع مشابه
Cholestatic jaundice caused by D-penicillamine.
D-penicillamine is not generally considered to cause hepatic damage. Cholestatic jaundice developed in a patient with rheumatoid arthritis 4 weeks after penicillamine was added to his regimen, and he died in acute renal failure. The probability that penicillamine caused the cholestasis is discussed.
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ورودعنوان ژورنال:
- The Malaysian journal of pathology
دوره 7 شماره
صفحات -
تاریخ انتشار 1985