Clinical Vignette: Early-Onset Head and Neck Cancer: Beware of Fanconi Anaemia!
نویسندگان
چکیده
Our department recently received a letter of referral from an otolaryngologist concerning a 31-year-old Caucasian male with inoperable (T4N2c) squamous cell cancer of the base of his tongue. According to this letter, a brother of the patient had died from early-onset cancer of the soft palate a few years ago. The patient and his two healthy siblings were referred with the question whether or not a hereditary cancer-predisposing disorder was present in this family. The letter also mentioned the fact that the patient would receive an experimental combination of radiation treatment and chemotherapy. Clinical Vignette: Early-Onset Head and Neck Cancer: Beware of Fanconi Anaemia!
منابع مشابه
Outcome of tongue cancer and early diagnosis
Back ground and Objective:Oral cancer is primarily a disease of epithelial origin. The tongue is the most common site of oral cancer. The aim of this study was to determine the frequency of tongue cancer and signs, symptoms, clinical features, and site of lesions in addition to factors affected this cancer. Materials Methods and:Twenty eight medical records of patients who a...
متن کاملAcquisition of Relative Interstrand Crosslinker Resistance and PARP Inhibitor Sensitivity in Fanconi Anemia Head and Neck Cancers.
PURPOSE Fanconi anemia is an inherited disorder associated with a constitutional defect in the Fanconi anemia DNA repair machinery that is essential for resolution of DNA interstrand crosslinks. Individuals with Fanconi anemia are predisposed to formation of head and neck squamous cell carcinomas (HNSCC) at a young age. Prognosis is poor, partly due to patient intolerance of chemotherapy and ra...
متن کاملHead and Neck Squamous Cell Carcinoma in Fanconi Anemia Patients
Head and neck cancers are among the most common tumors to develop in patients with Fanconi anemia.1,2 Although these tumors are histopathologically similar to those in patients without FA, the frequency, distribution, and clinical course are significantly different and must be taken into account when considering cancer management in patients with FA (Table 1). This chapter provides an overview ...
متن کاملPrevalence of Head and Neck Cancer in Gilan Province, Iran: A 10-Year Study
Background and aim: Head and neck cancers are the tenth most common cancers worldwide. Since these cancers can cause severe complications and mortality, early diagnosis and investigation of their prevalence in various regions may be life-saving. Therefore, this study evaluated the prevalence of head and neck cancer over a 10-year period in Gilan province, Iran. Materials and methods: This is a...
متن کاملNeuroendocrine Adenoma of Middle Ear Causing Acute Onset Facial Palsy- A Rare Case Report
Introduction: Acute facial nerve palsy secondary to neuroendocrine adenoma of the middle ear (NAME) is a rare disorder. There is only one case report in the literature describing similar findings. Case Report: A 50-year-old man initially presented to ENT clinic with a right-sided middle ear mass and normal facial nerve function. Over the next six days,...
متن کامل