Ability of monophosphoryl lipid A to augment the antibody response of young mice.

نویسندگان

  • P J Baker
  • J R Hiernaux
  • M B Fauntleroy
  • P W Stashak
  • B Prescott
  • J L Cantrell
  • J A Rudbach
چکیده

Treatment with nontoxic monophosphoryl lipid A increased the magnitude of the immunoglobulin M (IgM) antibody response to type III pneumococcal polysaccharide in young (2- to 4-week-old) mice. This was accompanied by the appearance of significant numbers of IgG1- and IgG3- secreting antibody-forming cells in 4-week-old mice. These findings indicate that monophosphoryl lipid A can be used as an adjuvant to improve the immunogenicity of poorly immunogenic antigens in young, immunologically immature animals.

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عنوان ژورنال:
  • Infection and immunity

دوره 56 12  شماره 

صفحات  -

تاریخ انتشار 1988