Somatic D816V KIT mutation in a case of adult-onset familial mastocytosis.

Rank # Genes Highest OR (L95-U95) Smallest P-value # Genes Highest OR (L95-U95) Smallest P-value # Genes Highest OR (L95-U95) Smallest P-value 1 IRAK1 0.70 (0.55-0.90) 0.006 IRAK1 0.73 (0.54-0.99) 0.042 IRAK1 0.50 (0.28-0.86) 0.013 2 MKK3 1.28 (1.10-1.50) 0.002 IRAKM 0.53 (0.31-0.90) 0.019 SIGIRR 0.54 (0.35-0.85) 0.008 3 ERK2 1.22 (1.05-1.42) 0.010 RIP1 1.49 (1.04-2.12) 0.012 TRAF6 0.65 (0.46-0.90) 0.009 4 IKBKE 0.68 (0.51-0.91) 0.010 JNK2 0.78 (0.65-0.94) 0.010 MKK6 2.29 (1.23-4.25) 0.009 5 Mek1 1.33 (1.00-1.76) 0.025 MKK6 0.55 (0.31-0.95) 0.029 TAB2 0.63 (0.46-0.86) 0.004 6 TOLLIP 0.82 (0.70-0.96) 0.009 MKK3 1.27 (1.05-1.53) 0.014 IRAK4 0.42 (0.20-0.89) 0.024 7 JNK2 1.42 (1.07-1.87) 0.014 IL1RL1 0.79 (0.65-0.96) 0.015 MyD88 2.07 (1.10-3.90) 0.024 8 SIGIRR 0.77 (0.62-0.95) 0.014 IRF7 0.74 (0.56-0.98) 0.029 IKBKE 1.47 (1.08-1.98) 0.013 9 TAB2 0.82 (0.70-0.95) 0.009 NFKB1 0.61 (0.39-0.97) 0.034 RIP1 1.85 (1.05-3.25) 0.034 10 TAB1 0.83 (0.71-0.97) 0.022 TIRAP 1.65 (1.01-2.69) 0.045 TRAM1 1.75 (1.02-3.01) 0.043 11 AKT1 0.77 (0.61-0.98) 0.030 IRF3 0.76 (0.59-0.98) 0.031 P38 1.67 (1.03-2.72) 0.039 12 IRF3 0.79 (0.64-0.97) 0.026 Mek1 1.25 (1.02-1.53) 0.032 JNK1 1.60 (1.03-2.48) 0.038 13 IRAKM 1.24 (1.04-1.47) 0.015 AKT1 1.25 (1.01-1.55) 0.037 JNK2 1.51 (1.04-2.20) 0.030 14 RIP1 1.38 (1.03-1.84) 0.029 AP1 0.68 (0.46-1.00) 0.049 15 TAK1 1.30 (1.03-1.64) 0.026 16 TRAM1 1.37 (1.01-1.86) 0.045 17 NFKB1 0.68 (0.47-1.00) 0.048 18 IL1RL1 0.84 (0.72-0.99) 0.031 19 MKK4 1.25 (1.00-1.55) 0.047