Hydrogen Sulfide: Next Potent Preventive and Therapeutic
نویسندگان
چکیده
21 Hydrogen sulfide (H2S) is the third endogenous signaling gasotransmitter, following 22 nitric oxide and carbon monoxide. It is physiologically generated by cystathionine-γ-lyase, 23 cystathionine-β-synthase, and 3-mercaptopyruvate sulfurtransferase. H2S has been gaining 24 increasing attention as an important endogenous signaling molecule because of its 25 significant effects on the cardiovascular and nervous systems. Substantial evidence shows 26 that H2S is involved in aging by inhibiting free-radical reactions, activating SIRT1, and 27 probably interacting with the age-related gene Klotho. Moreover, H2S has been shown to 28 have therapeutic potential in age-associated diseases. This article provides an overview of 29 the physiological functions and effects of H2S in aging and age-associated diseases, and 30 proposes the potential health and therapeutic benefits of H2S. 31
منابع مشابه
Pathophysiological Concepts in Multiple Sclerosis and the Therapeutic Effects of Hydrogen Sulfide
Introduction: Multiple sclerosis (MS) is generally known as a manageable but not yet curable autoimmune disease affecting central nervous system. A potential therapeutic approach should possess several properties: Prevent immune system from damaging the brain and spinal cord, promote differentiation of oligodendrocyte progenitor cells (OPCs) into mature oligodendrocytes to p...
متن کاملHydrogen Sulfide: Potent Regulator of Vascular Tone and Stimulator of Angiogenesis
Hydrogen sulfide is the "third" gasotransmitter on the rise in cardiovascular research. Recent studies show that hydrogen sulfide has a great potential in the regulation of vascular tone of systemic arteries and many molecular targets are discussed. However, the complex mechanism of vascular tone regulation by hydrogen sulfide is only incompletely understood. It seems that a potent interaction ...
متن کاملRemoval of H2S and COD Using UV, Ferrate and UV/Ferrate from Municipal Wastewater
Background; The aim of this study is to compare UV, ferrate (VI) and UV/ferrate (VI) methods for removal of hydrogen sulfide and chemical oxygen demand (COD) from municipal wastewater under a continuous condition. Methods; The experiment was divided into three parts: 1) pollutants removal by using ferrate (VI) alone; 2) pollutants removal using UV alone; 3) pollutants removal using a combina...
متن کاملHydrogen sulfide (H2S) releasing agents: chemistry and biological applications.
Hydrogen sulfide (H2S) is a newly recognized signaling molecule with very potent cytoprotective actions. The fields of H2S physiology and pharmacology have been rapidly growing in recent years, but a number of fundamental issues must be addressed to advance our understanding of the biology and clinical potential of H2S in the future. Hydrogen sulfide releasing agents (also known as H2S donors) ...
متن کاملHydrogen sulfide removal from biogas using chemical absorption technique in packed column reactors
The toxicity and corrosion potential of hydrogen sulfide in raw biogas underlines the need for biogas purification. Several techniques available for removal of hydrogen sulfide from biogas are out of the reach for common end users due to lack of knowledge, higher running costs, and insufficient operational skills. The present experimental study aims to propagate hydrogen sulfide removal techniq...
متن کامل