Endothelium-Derived Relaxing Factor From the Carotid Artery
نویسندگان
چکیده
Background and Purpose The goal of this study was to determine whether release of endothelium-derived relaxing factor (EDRF) from carotid artery in response to acetylcholine is altered by aging. Methods Responses were examined in arteries from Wistar rats 6 to 8 months old (young rats), 24 to 26 months old (old rats), and 30 to 32 months old (very old rats). We used a bioassay technique to measure release of EDRF from the carotid artery (donor vessel) and, in the same experiment, measured the diameter of pressurized donor arteries. Results Responses of the donor arteries and the detector vessels (aortas) to sodium nitroprusside were not altered in old (24 to 26 months) and very old (30 to 32 months) rats compared with responses in the young rats. Dilator responses
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