The Immunologic and Clinicopathologic Heterogeneity of Cutaneous Lymphomas Other Than

Twenty-one cases of non-Hodgkin s lymphoma with cutaneous involvement, other than mycosis fungoides, were evaluated immunologically, histologically, and clinically. Ten patients presented with skin disease alone, seven with concurrent cutaneous and extracutaneous disease, and four with extracutaneous disease only. Twenty of the 21 cases were nonepidermotropic tumors and were equally likely to express B or T phenotypes. None of the cases expressed a true histiocytic phenotype. Almost all cases expressed Ia and class I HLA determinants. Immunophenotypes were stable regardless of time interval. therapy. or body site sampled in seven of eight patients studied serially. In contrast to mycosis fungoides, the T lymphomas exhibited noncerebniform cytology. tumor Ia expression. lack of mature helper T-cell phenotye. nonepidermotropic histology. a tendency for marrow involvement. and prosented as nodules rather than patches or plaques. Since