Immunological and Chemical Investigations of Vaccine Virus Iv. Statistical Studies of Elementary Bodies in Relation to Infection and Agglutination* By
نویسنده
چکیده
The exact relation of the elementary bodies of vaccinia to the causative agent of the disease has long been a subject of discussion. Recent observations of others as well as those made by us indicate that it is an intimate one, and that in general the infectivity of a suspension is related to the number of elementary bodies contained therein (1, 2, 3). Furthermore, the agglutinating properties of a suspension are related to the number of elementary bodies present. However, exact observations are lacking, and since, because of technical difficulties, the possibility of obtaining direct proof of infectivity by the inoculation of a single elementary body seems remote, the present work was undertaken with the object of applying statistical methods to the elucidation of the problems.
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