Respiratory protease/antiprotease balance determines susceptibility to viral infection and can be modified by nutritional antioxidants.
نویسندگان
چکیده
The respiratory epithelium functions as a central orchestrator to initiate and organize responses to inhaled stimuli. Proteases and antiproteases are secreted from the respiratory epithelium and are involved in respiratory homeostasis. Modifications to the protease/antiprotease balance can lead to the development of lung diseases such as emphysema or chronic obstructive pulmonary disease. Furthermore, altered protease/antiprotease balance, in favor for increased protease activity, is associated with increased susceptibility to respiratory viral infections such as influenza virus. However, nutritional antioxidants induce antiprotease expression/secretion and decrease protease expression/activity, to protect against viral infection. As such, this review will elucidate the impact of this balance in the context of respiratory viral infection and lung disease, to further highlight the role epithelial cell-derived proteases and antiproteases contribute to respiratory immune function. Furthermore, this review will offer the use of nutritional antioxidants as possible therapeutics to boost respiratory mucosal responses and/or protect against infection.
منابع مشابه
The respiratory protease / antiprotease balance determines susceptibility to viral 1 infection and can be modified by nutritional antioxidants
The respiratory protease/antiprotease balance determines susceptibility to viral 1 infection and can be modified by nutritional antioxidants 2 Megan Meyer, Ilona Jaspers 3 Department of Microbiology and Immunology, University of North Carolina at Chapel 4 Hill, Chapel Hill, NC 5 Center for Environmental Medicine, Asthma and Lung Biology, University of North 6 Carolina at Chapel Hill, Chapel Hil...
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ورودعنوان ژورنال:
- American journal of physiology. Lung cellular and molecular physiology
دوره 308 12 شماره
صفحات -
تاریخ انتشار 2015