A Comprehensive Review on Buccal Drug Delivery System

Bioadhesion can be defined as a phenomenon of interfacial molecular attractive forces in the midst of the surfaces of biological substrate and the natural or synthetic polymers, which allows the polymer to adhere to biological surface for an extended period of time. Within the oral mucosal cavity, the buccal region offers an adorable route of administration for systemic drug delivery. Among the various transmucosal sites available, mucosa of the buccal cavity was found to be the most convenient and easily approachable site for the delivery of therapeutic agents for both local and systemic delivery as retentive dosage form because buccal drug delivery system prolong the residence time of dosage form at the site and thus contribute to improved and/or better therapeutic performance of the drug. In this paper main focus is done on oral mucosa, pathway, barriers to penetration of drug, different dosage forms, evaluation methods; this will be useful to circumvent the difficulties associated with the formulation design.