Donor CMV serological status and outcome of CMV seropositive recipients after unrelated donor stem cell transplantation; An EBMT Megafile analysis
نویسندگان
چکیده
1. Dept of Hematology, Huddinge University Hospital, Stockholm, Sweden 2. Department of Medical Statistics, Leiden University Medical Centre, Leiden, the Netherlands 3. Department of Medicine, University Hospital, Tübingen, Germany 4. Department of Hematology, Ospedale San Martino, Genova , Italy 5. Department. of Haematology/Oncology, University of Leipzig. Leipzig, Germany 6. Department of. Hematology, Hôpital Henri Mondor, Creteil , France
منابع مشابه
Donor CMV serologic status and outcome of CMV-seropositive recipients after unrelated donor stem cell transplantation: an EBMT megafile analysis.
Cytomegalovirus (CMV) has been a major cause of morbidity and mortality after allogeneic stem cell transplantation (SCT). The importance of the recipient's serologic status is paramount. However, the importance of the donor's serologic status in CMV-seropositive recipients is controversial. We analyzed the influence of the donor's CMV status in a large cohort of patients. A total of 7018 patien...
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Patient MV serological status remains an important factor for the outcome of allogeneic stem cell transplantation (SCT). CMV seronegative patients receiving a graft from a seronegative donor have lower transplant-related mortality. In a previous study using the EBMT registry, we found that CMV seropositive patients receiving grafts from seropositive unrelated donors had improved survival and re...
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In solid organ transplant and in stem cell transplant, the impact of the cytomegalovirus (CMV) serologic status of both the donor and recipient have been the subject of intense scrutiny [1, 2]. In both types of transplants, it has been clear that CMV status can play a significant role in the outcome. In solid organ transplant, CMV donor seropositivity has been well established to lead to an inc...
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In the current era of effective prophylactic and preemptive therapy, cytomegalovirus (CMV) is now a rare cause of early mortality after hematopoietic stem cell transplantation (HSCT). However, the ultimate goal of completely eliminating the impact of CMV on survival remains elusive. Although the direct effects of CMV (ie, CMV pneumonia) have been largely eliminated, several recent cohort studie...
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BACKGROUND Cardiac allograft vasculopathy (CAV) is initiated by allograft endothelial injury. We hypothesized that a major mechanism by which cytomegalovirus (CMV) could contribute to CAV is by dysregulation of the endothelial vasomotor response. METHODS Coronary endothelial vasomotor function was determined in 183 consecutive patients (24+/-33 months after transplantation), and was correlate...
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