Immune-mediated arrest and reversal of established visceral metastases in athymic mice.

Inhibition of Friend leukemia cell visceral metastases by a new monoclonal antibody and role of the immune system of the host in its action.

We developed a syngeneic mouse IgG2a monoclonal antibody (MAb) A9D41 directed against the Friend leukemia virus envelope gp70 antigen present on the cell surface membranes of virus producer 3C18 Friend leukemia cells (FLC). A9D41 showed a marked antitumor activity in DBA/2 mice given injections of gp70 positive 3C18 FLC, but it was ineffective in mice given injections of gp70 negative 745 FLC o...

Testicular stereological and histological changes in an experimental murine model of visceral leishmaniasis

Background and Aim: Visceral leishmaniasis, a native disease in developing countries, can cause functional impairment in various organs, including the reproductive system, which can lead to infertility. The aim of this study was to evaluate the stereological, morphometric and morphological changes of testicular histoarchitecture in an experimental murine model of visceral leishmaniasis in BALB/...

Reversal of Electrocardiographic Sodium Channel Blockade Changes with Bicarbonate Therapy in a Pediatric Patient Post-Cardiopulmonary Arrest Secondary to Methadone Toxicity

Evaluation of pharmacological mechanisms of antinociceptive effect of Teucrium polium on visceral pain in mice

Teucrium polium is used for treatment of visceral pain in Iranian folkloric medicine. In this studyantinociceptive mechanisms of T. polium hydroethanolic extract were examined by acetic acid-inducedwrithing test as a model of visceral pain in male NMRI mice. To reveal the antinociceptive mechanisms ofthe extract, we examined the effects of opioidergic, serotonergic, adrenergic and histaminergic...

Anti - Transforming Growth Factor ( TGF ) - , B Antibodies Inhibit Breast Cancer Cell Tumorigenicity and Increase Mouse Spleen Natural Killer Cell Activity

TGF-0 effects on angiogenesis, stroma formation, and immune function suggest its possible involvement in tumor progression. This hypothesis was tested using the 2G7 IgG2b, which neutralizes TGF-fil, -,82, and -,83, and the MDA-231 human breast cancer cell line. Inoculation of these cells in athymic mice decreases mouse spleen natural killer (NK) cell activity. Intraperitoneal injections of 2G7 ...