Acute Effects on Protein Synthesis in Rabbits With Normal and Increased Fibrinogen Production
نویسندگان
چکیده
The acute effects of a single intravenous dose of iasparaginase on protein synthesis were studied in normal rabbits and in animals that had received turpentine to stimulate fibrinogen production. Male New Zealand rabbits received 1-asparaginase (500 U/kg) 16 hr before the injection of the radiolabeled amino acid [75Sejselenomethionine (75SeM). Incorporation of 75SeM into fibrinogen and serum proteins in the i-asparaginase-treated rabbits was the same as for saline-treated controls. with fibrinogen representing approximately 5% of the labeled plasma proteins. In turpentine-treated rabbits, the maximal incorporation of 75SeM into serum proteins remained unchanged, whereas 75SeM-fibrinogen increased sixfold and accounted for 25%
منابع مشابه
L-asparaginase: acute effects on protein synthesis in rabbits with normal and increased fibrinogen production.
The acute effects of a single intravenous dose of L-asparaginase on protein synthesis were studied in normal rabbits and in animals that had received turpentine to stimulate fibrinogen production. Male New Zealand rabbits received L-asparaginase (500 U/kg) 16 hr before the injection of the radiolabeled amino acid [75Se]selenomethionine (75SeM). Incorporation of 75SeM into fibrinogen and serum p...
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