Research Article
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چکیده
The cell-cell adhesion systems are involved in neuronal cell migration, axon-bundle formation, target-cell recognition, activity-dependent plasticity of synapses, and formation of complex glial networks, which surround axons and synapses (for a review, see Redies and Takeichi, 1996). The cell-cell adhesion molecules implicated in brain function are classified into two superfamilies, the cadherin and immunoglobulin (Ig) superfamilies. Among the cadherin superfamily, N-cadherin localizes at both synaptic and puncta adherentia junctions of a certain set of neurons and plays a role in the formation and maintenance of these junctions (Yamagata et al. Synaptic junctions include presynaptic active zones, where synaptic vesicles and Ca 2+ channels localize, and postsynaptic densities, where neurotransmitter receptors localize. Puncta adherentia
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