Mrp3 transports clopidogrel aryl glucuronide from the hepatocytes into blood
نویسنده
چکیده
General Clinical Research Center, Nanjing First Hospital, Nanjing Medical University (J.Z.J., T.T., B.B.H., T.T.G., Q.Y.M., H.G.X.); Department of Clinical Pharmacy, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University (H.G.X.); and Departments of Pharmacology and Clinical Pharmacy, Nanjing Medical University School of Pharmacy (H.G.X.), Nanjing, China This article has not been copyedited and formatted. The final version may differ from this version. DMD Fast Forward. Published on December 1, 2017 as DOI: 10.1124/dmd.117.078329
منابع مشابه
Correction to "Mrp3 Transports Clopidogrel Acyl Glucuronide from the Hepatocytes into Blood".
Clopidogrel acyl glucuronide (CLP-G) is a major phase II metabolite of clopidogrel generated in the liver for further excretion into urine; however, it is unclear whether CLP-G transports from hepatocytes into blood. Because multidrug resistance-associated protein 3 (MRP3) is predominantly expressed in the sinusoidal side of hepatocytes and preferentially transports glucuronide conjugates of dr...
متن کاملMrp3 transports clopidogrel acyl glucuronide from the hepatocytes into blood
General Clinical Research Center, Nanjing First Hospital, Nanjing Medical University (J.Z.J., T.T., B.B.H., T.T.G., Q.Y.M., H.G.X.); Department of Clinical Pharmacy, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University (H.G.X.); and Departments of Pharmacology and Clinical Pharmacy, Nanjing Medical University School of Pharmacy (H.G.X.), Nanjing, China This article ha...
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