Microbial β‐lactone natural products

Microbial b-lactone natural products An annotated selection of World Wide Web sites relevant to the topics in microbial biotechnology. Obafluorin is an antimicrobial b-lactone compound produced by the bacterium Pseudomonas fluorescens. In this study, the compound was synthesized, analysed chemically and tested for biological activity. The triedimycins are a class of spiro b-lactones. They are not potent as antibiotics but show substantial in vitro antitumor activity against murine leukaemia cells. b-Lactone natural products inactivate homoserine transacetylase The b-lactone ebelactone A served as a lead compound to find potent inhibitors that inactivated homoserine transacetylase. Inhibition against that enzyme makes for a useful antimicrobial substance against pathogens, such as Haemophilus influenzae. This commercial website contains useful information on the b-lactone antibiotic and antifungal agent, (R,R)-hymeglusin. This patent builds off a knowledge of b-lactone natural products. Novel hydrophobic b-lactone structures with alkenyl, alkynyl and phenyl groups were synthesized to test as novel antimicrobial substances. Methylene-substituted b-lactones are intermediates in the synthesis of mimics of b-lactone natural products. The general characteristics of a simple methylene b-lac-tone are available here. Tetrahydrolipstatin is a b-lactone antiobesity drug, currently available with or without prescription. The Pub-chem website for this compound has information on chemical properties, biological assays and commercial availability. Lipstatin is the b-lactone natural product produced by a Streptomyces species that can be reduced to make the drug tetrahydrolipstatin. The patent was filed to protect certain aspects of the fermentative production of the compound. b-Lactones as synthetic intermediates for natural products The b-lactone functional group is described here in this thesis for its value in the synthesis of natural products. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.