"Pierce and inhale" design in capsule based dry powder inhalers: Effect of capsule piercing and motion on aerodynamic performance of drugs.

Delivery characteristics of a low-resistance dry-powder inhaler used to deliver the long-acting muscarinic antagonist glycopyrronium*

OBJECTIVES The long-acting muscarinic antagonist (LAMA) glycopyrronium (NVA237) has recently been approved as a once-daily treatment for COPD. The objectives of this study were to determine the dose delivery characteristics of glycopyrronium and compare them with those of the LAMA tiotropium, both delivered by their respective capsule-based dry-powder inhalers (DPIs). RESEARCH DESIGN AND METH...

Impact of capsule selection on formulation stability in dry powder inhalers (DPIs)

The delivery of inhalation-based formulations is achieved by devices that fall into three segments: nebulizers, metered dose inhalers (MDIs), and dry powder inhalers (DPIs).2 There is much discussion about which device is most appropriate, though that discussion is well beyond the scope of this article. It is of note however, that MDIs and DPIs have been shown to function equally well when pati...

from Capsule - Based Dry Powder Inhalers

Pharmaceutical equivalence of the combination formulation of budesonide and formoterol in a single capsule with a dry powder inhaler.

OBJECTIVE To evaluate the pharmaceutical equivalence of a test formulation (fixed-dose combination of budesonide and formoterol fumarate in a single capsule dispensed in an Aerocaps® inhaler) in relation to a reference formulation (budesonide and formoterol fumarate in two separate capsules dispensed in an Aerolizer® inhaler). METHODS This was an in vitro study in which we performed the ident...

Delivery characteristics and patients’ handling of two single-dose dry-powder inhalers used in COPD

For optimal efficacy, an inhaler should deliver doses consistently and be easy for patients to use with minimal instruction. The delivery characteristics, patients' correct use, and preference of two single-dose dry powder inhalers (Breezhaler and HandiHaler) were evaluated in two complementary studies. The first study examined aerodynamic particle size distribution, using inhalation profiles o...