Change in Recessive Lethal Alleles Frequency in Inbred Populations
نویسنده
چکیده
In a population practicing consanguineous marriage, rare recessive lethal alleles (RRLA) have higher chances of affecting phenotypes. As inbreeding causes more homozygosity and subsequently more deaths, the loss of individuals with RRLA decreases the frequency of these alleles. Although this phenomenon is well studied in general, here some hitherto unstudied cases are presented. An analytical formula for the RRLA frequency is presented for infinite monoecious population practicing several different types of inbreeding. In finite diecious populations, it is found that more severe inbreeding leads to quicker RRLA losses, making the upcoming generations healthier. A population of size 10,000 practicing 30% half-sib marriages loses more than 95% of its RRLA in 100 generations; a population practicing 30% cousin marriages loses about 75% of its RRLA. Our findings also suggest that given enough resources to grow, a small inbred population will be able to rebound while losing the RRLA.
منابع مشابه
Evidence of the phenotypic expression of a lethal recessive allele under inbreeding in a wild population of conservation concern.
Deleterious recessive alleles that are masked in outbred populations are predicted to be expressed in small, inbred populations, reducing both individual fitness and population viability. However, there are few definitive examples of phenotypic expression of lethal recessive alleles under inbreeding conditions in wild populations. Studies that demonstrate the action of such alleles, and infer t...
متن کاملTwo classes of deleterious recessive alleles in a natural population of zebrafish, Danio rerio.
Natural populations carry deleterious recessive alleles which cause inbreeding depression. We compared mortality and growth of inbred and outbred zebrafish, Danio rerio, between 6 and 48 days of age. Grandparents of the studied fish were caught in the wild. Inbred fish were generated by brother-sister mating. Mortality was 9% in outbred fish, and 42% in inbred fish, which implies at least 3.6 l...
متن کاملGenetic Drift in Irradiated Experimental Populations of Drosophila Melanogaster.
HE investigation reported in the present paper is of the effects of genetic T drift in three experimental populations of Drosophila melanogastar, two of which received treatments with gamma rays. Although there has been considerable theoretical discussion of genetic drift, few experimental studies of this phenomenon have been carried out. This paucity of experimental verification exists in spit...
متن کاملIs lack of evidence of inbreeding depression in a threatened New Zealand robin indicative of reduced genetic load?
Continuous inbreeding exposes deleterious recessive alleles to selection and can thereby lead to partial purging of the genetic load and reduced inbreeding depression. Purging has been well documented in experimental laboratory populations, but evidence of reduced inbreeding depression due to purging in wild populations is largely lacking. This study examines the inbreeding load associated with...
متن کامل