Saccharated Ferric Oxide-Induced Osteomalacia in Iron-Induced Osteopathy Due to Nephropathy
نویسنده
چکیده
Adult-onset hypophosphatemic osteomalacia is very rare in well-developed countries [1]. The most likely diagnosis of such patients, if their diet contains enough vitamin D, is oncogenic or iatrogenic osteomalacia [2, 3]. Saccharated ferric oxide (SFO; [Fe(OH)3]m [C12H22O11]n) is an intravenous preparation indicated for patients with iron-deficiency anemia [4, 5]. Since its introduction into the medical market in 1961, SF0 has been used widely in Japan for iron-deficiency anemia. SF0 is prepared by coating ferric iron with polysaccharide to reduce the irritancy and toxicity of iron. After intravenous administration, the colloidal iron is incorporated immediately into the reticuloendothelial system of the liver and spleen, where the iron is sequestrated and stored as ferritin and hemosiderin. Some iron is released from the iron store, binds tightly to transf errin and circulates in the blood stream, and is taken up by erythroid cells in the bone marrow, leading to stimulation of erythropoiesis and improvement of iron-deficiency anemia [4, 6]. One vial of SFO contains 40 mg iron, almost equivalent to the daily flow of iron through the peripheral blood [6]. In view of the fact that the male and female body content of iron is 50 and 37 mg/kg, respectively [6],10 to 20 vials would be usually sufficient to treat a patient with moderate anemia. However, over 7 million vials were consumed per
منابع مشابه
A case of osteomalacia due to deranged mineral balance caused by saccharated ferric oxide and short-bowel syndrome
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UNLABELLED CASE 1: An 80-year-old man presented at our hospital with pain in both knees.He had received continuous intravenous administration of saccharated ferric oxide (SFO) over a period of five years following a diagnosis of iron-deficiency anemia.Blood tests revealed hypophosphatemia (1.4 mg/dl) and high circulating levels of fibroblast growth factor 23 (FGF23) at 248.8 mg/dl.These finding...
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