Sleep Microarchitecture in Depression: Association with Response to Bupropion Treatment
نویسنده
چکیده
There are a number of reasons to consider the regulation of sleep as an essential component for understanding the pathophysiology and treatment of depression (1). For instance, sleep complaints are commonly associated with depression and form an essential criterion of the diagnosis (2). Persistent sleep disturbances increase the vulnerability to depression (3,4). EEG sleep changes associated with major depressive disorder are the best replicated findings in biological psychiatry (5,6). Many antidepressant agents affect sleep, some on REM sleep and others on slow-wave sleep (SWS) (1,7-9). Also, antidepressant efficacy, for at least some drugs, can be predicted from baseline sleep polysomnographic measures (10), as well as from EEG sleep changes in Sleep Microarchitecture in Depression: Association with Response to Bupropion Treatment
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