Editorial 1.p65
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چکیده
With increase in global warming, the problems of hyperthermia have recently attracted worldwide medical attention. Deaths due to heat-related illnesses in large number of human population in recent years are now recognised as a great social and medical problem. Interestingly, details of mechanisms involved and probable therapeutic measures have still not been worked out and thus require further investigation using latest available technology.
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Editorial 1.p65
It is appropriate to consider progress in the control of tuberculosis on March 24th, World Tuberculosis Day. While an effective vaccine that would kill dormant tubercle bacilli would be a real solution to eradication of the disease, progress in vaccine development is very slow and unlikely to produce a new vaccine with this desirable property in the near future. Control of the disease therefore...
متن کاملاثر مهاری کورکومین بر فسفریلاسیون NFκB-p65 القاشده توسط هیدروژن پراکسید در سلول‌های اندوتلیال آئورت گاوی
زمینه و هدف: NFκB یک فاکتور هسته‌ای دایمر و دارای چندین زیرواحد است. p65 یکی از زیرواحدهای NFκB است که فسفریلاسیون آن در اثر استرس اکسیداتیو به فعال شدن NFκB منجر می‌گردد. عدم تعادل میان استرس اکسیداتیو و ظرفیت آنتی‌اکسیدانی در پاتوژنز بسیاری بیماری‌ها مشارکت می‌کند. استفاده از ترکیبات آنتی‌اکسیدانی می‌تواند به‌عنوان استراتژی پیشگیری بیماری‌های التهابی موردتوجه قرار گیرد. از میان ترکیبات آنتی‌ا...
متن کاملThe effects of adenosine injection after of brain ischemia reperfusion injury on gene expression of NF-kB/p65 and activity level of ROS in male Wistar rats
Background: Unit of p65 is one of the subunits of NF-κB and its phosphorylation by stress oxidative causes activation of NF-κB. The aim of present study was to investigate the effects of adenosine injection after brain ischemia reperfusion injury on gene expression of NF-κB /p65 and Reactive Oxygen Species (ROS) in hippocampus tissue of male wistar rats. Methods: 40 male wistar rats were rando...
متن کاملApurinic/apyrimidinic endonuclease-1 (APE-1) is overexpressed via the activation of NF-κB-p65 in MCP-1-positive esophageal squamous cell carcinoma tissue
Apurinic/apyrimidinic endonuclease-1 (APE-1), a key enzyme responsible for DNA base excision repair (BER), has been linked to cancer chemoradiosensitivity. The phosphorylation of p65 plays a role in the activation of this pathway. In this study, we investigated APE-1 expression and its interaction with p65 in esophageal squamous cell carcinoma (ESCC) tissue. The expression of APE-1, p65, p65 nu...
متن کاملNuclear NF-κB p65 in Peripheral Blood Mononuclear Cells Correlates with Urinary MCP-1, RANTES and the Severity of Type 2 Diabetic Nephropathy
AIMS To investigate if nuclear NF-κB p65 expression in ex vivo isolated peripheral blood mononuclear cells correlates with urinary MCP-1 or RANTES and the severity of type 2 diabetic nephropathy. METHODS According to their urinary albumin-to-creatinine ratio (uACR), 107 patients with type 2 diabetes (eGFR >60 ml/min) were divided into normal albuminuria group (DN0 group, 38 cases), microalbum...
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