British anti-lewisite as an antidote for acute mercury poisoning.
نویسنده
چکیده
منابع مشابه
Use of BAL in the Treatment of Arsenical Neuropathy
BAL 01* British Anti-Lewisite which is 2, 3 dimercaptopropanol was evolved in Professor Peters' Laboratory at Oxford by Peters, Stocken and Thompson in 1945, as an effective antidote to Lewisite. It has since been used successfully in several forms of metallic poisoning including arsenic, mercury and other heavy metals. Eagle and Magnuson (1946) found it efficacious in 5 cases of arsenical ence...
متن کاملClinical Uses of 2,3-dimercaptopropanol (bal). Xi. the Treatment of Acute Mercury Poisoning by Bal.
The extensive investigations upon the mechanism by which arsenic poisons the protoplasm of cells (1, 2) and the discovery (1) that the di-thiol, 2,3-dimercaptopropanol or BAL (British AntiLewisite), possesses an avidity for Lewisite and trivalent arsenicals, thus sparing injury to the cells and their essential enzymes, led to the suggestion that the toxic action of other metals might be explain...
متن کاملClinical Uses of 2,3-dimercaptopropanol (bal). Vii. the Treatment of Arsenical Dermatitis with Preparations of Bal.
The development of 2,3-dimercaptopropanol (British Anti-Lewisite, BAL) by Peters, Stocken, and Thompson (1) has made available a potent antidote for arsenical poisoning. Study of the chemical combination of arsenic with sensitive enzymes and cells indicated that the arsenic could, under certain circumstances, be removed from the cells, and that enzymes could be reactivated by the action of BAL ...
متن کاملTreating exposure to chemical warfare agents: implications for health care providers and community emergency planning.
Current treatment protocols for exposure to nerve and vesicant agents found in the U.S. stockpile of unitary chemical weapons are summarized, and the toxicities of available antidotes are evaluated. The status of the most promising of the new nerve agent antidotes is reviewed. In the U.S. atropine and pralidoxime compose the only approved antidote regimen for organophosphate nerve agent poisoni...
متن کاملClinical Uses of 2,3-dimercaptopropanol (bal). X. the Treatment of Acute Systemic Mercury Poisoning
Although chemical agents were not employed as offensive weapons during the past war, nevertheless it was imperative to pursue vigorously investigations on the treatment of chemical warfare casualties. Inasmuch as a number of chemical warfare agents contain arsenic, attention was focused on the synthesis of compounds capable of antagonizing the local and systemic effects of arsenical vesicants. ...
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ورودعنوان ژورنال:
- The Biochemical journal
دوره 41 3 شماره
صفحات -
تاریخ انتشار 1947