Partially Agonistic Peptide Ligands Activated CTL by Immunogenic and Cell Death Are Triggered in Mature Different Programs of Activation-Induced
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From MICROBIOLOGY AND TUMOR BIOLOGY CENTER Karolinska Institutet, Stockholm, Sweden REGULATION OF NON-RESPONSIVENESS AND DEATH IN CYTOTOXIC T CELLS BY THE AGONISTIC POTENCY OF MHC:PEPTIDE LIGANDS
CD8+ T lymphocytes are important for immunological control of infections and tumors. The key interaction required to initiate the process of T cell activation is the engagement of the T cell receptor (TCR) with a major histocompatibility complex (MHC) class I/peptide complex on an antigen presenting cell (APC). Depending on the affinity of the interaction between the TCR and MHC class I molecul...
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