Comparison of donor hearts from hypoxic cardiac arrest followed by warm ischemia and from exsanguination as non-beating donor models in rat heart transplantation
نویسندگان
چکیده
Background/Introduction Non-heart-beating donation, in the situation where a patient cannot be diagnosed as dead using brainstem criteria, may be an alternative to overcome shortage of donors. Preclinical studies showed that functional recovery of hearts after circulatory determination of death (DCDD) were similar to that of hearts from brain-dead donor. However, there are several experimental methods of simulating DCDD conditions such as exsanguination and hypoxic cardiac arrest both followed by warm ischemia.
منابع مشابه
The Donation after Circulatory Death Donor can be a Source of Organs for Cardiac Transplantation
The number of heart transplants performed worldwide is declining annually [1-3]. The conventional source of donor hearts, the brainstem dead cadaveric heart-beating donor. is decreasing. Advances in neurosurgical treatment of patients with severe head injury and intracranial haemorrhage (ICH) mean that the increase in intracranial pressure (ICH) which previously precipitated ischemic brain-stem...
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The rate of renal transplantation has plateaued and is now limited by the number of donor organs available. In the past all donor kidneys came from living donors or controlled non-heart beating donors. It was not until the introduction of brainstem death criteria that cadaveric heart beating donors became the main source. Recently, there has been renewed interest in non-heart beating donors, wh...
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BACKGROUND The shortage of donor hearts has made use of non-beating hearts as cardiac grafts an attractive possibility for heart transplant candidates. The purpose of this study was to evaluate the utility of leukocyte-depleted hot shot cardioplegia for resuscitation of non-beating hearts obtained from asphyxiated dogs via an autoperfusing heart-lung circuit. METHODS Mongrel dogs were divided...
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BACKGROUND The duration of warm ischemia and reperfusion injury is a major limiting factor in the setting of lung transplantation with non-heart-beating donors (NHBD). We hypothesized that reperfusion with neutrophil elastase inhibitor or leukocyte-depleted blood has an inhibitory effect on the ischemia-reperfusion injury of NHBD rabbit lungs. METHODS To assess the lung injury, we used a perf...
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