The Hox-2 homeo box gene complex on mouse chromosome 11 is closely linked to Re.

نویسندگان

  • C P Hart
  • D K Dalton
  • L Nichols
  • L Hunihan
  • T H Roderick
  • S H Langley
  • B A Taylor
  • F H Ruddle
چکیده

Restriction fragment length polymorphisms have been identified between inbred strains of mice for the homeo box gene complex Hox-2. These genetic markers were used to follow the segregation of different Hox-2 alleles among recombinant inbred strains of mice and among the progeny of a three point genetic cross. The results place the Hoax-2 locus approximately 1 cM from the rex (Re) locus on mouse chromosome 11.

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The Hox-2.1 gene is one of homeobox-containing genes located in lheHox-2 cluster on mouse chromosome 11. In this study, we have examined transcription of the Hox-2.1 gene during differentiation of F9 embryonal carcinoma cells induced by treatment with retinoic acid. The level of Hox-2.1 mRNA increases rapidly after induction of differentiation and then falls. Nuclear run-on experiments demonstr...

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عنوان ژورنال:
  • Genetics

دوره 118 2  شماره 

صفحات  -

تاریخ انتشار 1988