Association between gout and polymorphisms in SLC17A1 gene in male Han Chinese

Human sodium-dependent phosphate cotransporter type 1 encoded by SLC17A1 is a urate transporter localized to the renal proximal tubular cells and candidate molecule to secret urate from renal tubular cells to urine. The SLC17A1 locus was also found to be associated with serum urate concentration. However, evidence for association with gout was equivocal. In current study, we investigated the association of the SLC17A1 locus with gout in male Han Chinese. This was a case-control study in a group of 400 male patients with gout and 424 gout-free male controls to genotype the single-nucleotide polymorphism rs1165196, rs1183201 and rs3799344 of SLC17A1 gene. There were significant differences between gout and control groups in the allele frequencies at rs1165196 (T806C; Ile269Thr, odds ratio (OR) 0.758, P=0.027) and rs1183201 (OR 0.745, P=0.018). The allele frequencies of rs3799344 were not significantly associated with the development of gout (OR 0.811, P=0.064). The association was found between genotypes at rs1165196 and rs1183201 (P=0.032 and P=0.029) and serum uric acid (sUA) levels. The genotype status of rs1183201 was significantly associated with sUA using Multivariate regression analysis. However, there were no differences in the distribution of genotypes at rs1165196 (OR 1.121, P>0.05) and rs1183201 (OR 0.887, P>0.05) in patients with gout with kidney stones and without kidney stones. Our data suggest that SLC17A1 polymorphisms were associated with the development of gout in male Han Chinese.