An apolipoprotein influencing triglycerides in humans and mice revealed by comparative sequencing.

Detection of monoclonal proteins in sera by capillary zone electrophoresis and free light chain measurements.

idemia. Arterioscler Thromb 1993;13:804–14. 5. Austin MA, McKnight B, Edwards KL, Bradley CM, McNeely MJ, Psaty BM, et al. Cardiovascular disease mortality in familial forms of hypertriglyceridemia. Circulation 2000;101:2777–82. 6. Pajukanta P, Nuotio I, Terwilliger JD, Porkka KVK, Ylitalo K, Pihlajamäki J, et al. Linkage of familial combined hyperlipidemia to chromosome 1q21–q23. Nat Genet 199...

Allele Dropout in Pcr-based Diagnosis of Wilson Dis- Ease: Mechanisms

References 1. Willems Van Dijk K, Rensen PC, Voshol PJ, Havekes LM. The role and mode of action of apolipoproteins CIII and AV: synergistic actors in triglyceride metabolism. Curr Opin Lipidol 2004;15:239–46. 2. Pennacchio LA, Rubin EM. Apolipoprotein A5, a newly identified gene that affects plasma triglyceride levels in humans and mice. Arterioscler Thromb Vasc Biol 2003;23:529–34. 3. Pennacch...

New apolipoprotein A-V: comparative genomics meets metabolism.

The availability of the human genome sequence and the recently completed draft sequences of two major mammalian model species, the mouse (Mus musculus) and the rat (Rattus norvegicus), allow researchers to apply novel approaches for gene identification and characterization, using methods of comparative and functional genomics. Recently, a new gene coding for apolipoprotein A-V was identified in...

An apolipoprotein identified through comparative sequence analysis influences triglyceride levels in humans and mice

ATVB In Focus Lipoproteins, Inflammation, and Atherosclerosis

Apolipoprotein A5 (APOA5) is a newly described member of the apolipoprotein gene family whose initial discovery arose from comparative sequence analysis of the mammalian APOA1/C3/A4 gene cluster. Functional studies in mice indicated that alteration in the level of APOA5 significantly affected plasma triglyceride concentrations. Mice that overexpressed human APOA5 displayed significantly reduced...