Rapid Communication Angiotensin Converting Enzyme Inhibitors Attenuated the Expression of G-Protein Coupled Receptor Kinases in Heart Failure Patients
نویسندگان
چکیده
Lymphocyte GRK mRNA expression was measured by quantitative RT-PCR in 15 congestive heart failure patients: 5 in NYHA class-II treated with ACEI (IIA), 5 in NYHA class-II without ACEI (IIC) and 5 in NYHA class-III treated with ACEI (IIIA). GRK2 and GRK5 mRNA of IIIA were significantly higher than those in IIA. GRK mRNA expression level in IIA were significantly lower than those of IIC. These results suggest that the expression level of lymphocyte GRK may reflect the severity of CHF, and that ACEI treatment could reduce the level of GRK in CHF patients.
منابع مشابه
Angiotensin converting enzyme inhibitors attenuated the expression of G-protein coupled receptor kinases in heart failure patients.
BACKGROUND There are few biological markers, which strictly show the severity of congestive heart failure (CHF). METHODS AND RESULTS Lymphocyte G-protein coupled receptor kinase (GRK) mRNA expression was measured by quantitative reverse transcription-polymerase chain reaction in 15 CHF patients: 5 patients classified as New York Heart Association class-II treated with angiotensin converting e...
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