Anesthesia Differentially Modulates Spontaneous Network Dynamics by Cortical Area and Layer 1 2 Running Head : Differential Modulation of Cortical Activity by Anesthesia 3 4 5

Anesthesia Differentially Modulates Spontaneous Network Dynamics by Cortical Area and Layer 1 2 Running Head: Differential Modulation of Cortical Activity by Anesthesia 3 4 5 Kristin K. Sellers, Davis V. Bennett, Axel Hutt, and Flavio Frohlich 6 7 1 Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill NC 27599 8 2 Neurobiology Curriculum, University of North Carolina at Chapel Hill, Chapel Hill NC 27599 9 3 INRIA CR Nancy – Grand Est, Team Neurosys, Villers-les-Nancy, France 10 4 Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel Hill NC 11 27599 12 5 Department of Biomedical Engineering, University of North Carolina at Chapel Hill, Chapel Hill NC 13 27599 14 6 Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill NC 27599 15 16 17 Correspondence should be addressed to: Flavio Frohlich, 115 Mason Farm Rd. NRB 4109F, Chapel Hill, 18 NC. 27599. Email: [email protected] 19 20 Authorship Statement: KS, DB, and FF designed the experiments, KS, DB, and FF performed the 21 experiments, KS and FF analyzed the data, and KS, AH, and FF wrote the paper. 22 23 The authors declare no competing financial interests. 24 25 Articles in PresS. J Neurophysiol (September 18, 2013). doi:10.1152/jn.00404.2013