SpliceInfo: an information repository for the modes of mRNA alternative splicing in human genome
نویسندگان
چکیده
As an integrated database, SpliceInfo identifies automatically the conserved sequences in selected exon/intron regions of a gene group. Several modes of mRNA alternative splicing, such as exon skipping, alternative 5'-splicing sites, alternative 3'-splicing sites and mutually exclusive exons are computationally derived and extracted. Finally, for each type of alternative splicing, the flanking intronic sequences are collected and then exploited by motif discovery tools. The tissue-specific information and gene functionalities that correspond to the selected regions are also considered. The database provides a means of investigating alternative splicing and can be used for identifying alternative splicing related motifs, such as the exonic splicing enhancer (ESE), the exonic splicing silencer (ESS) and other intronic splicing motifs. The integrated resource is now available on http://140.113.239.236/SpliceInfo/.
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SpliceInfo: an information repository for mRNA alternative splicing in human genome
We have developed an information repository named SpliceInfo to collect the occurrences of the four major alternative-splicing (AS) modes in human genome; these include exon skipping, 5'-alternative splicing, 3'-alternative splicing and intron retention. The dataset is derived by comparing the nucleotide and protein sequences available for a given gene for evidence of AS. Additional features su...
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