Acute Myocardial Infarction in a Young Woman With Heterozygous Polymorphism for Methylenetetrahydro- folate Reductase and Prothrombin Gene Mutation
نویسندگان
چکیده
Many publications demonstrate a relationship between acute myocardial infarction and genetic mutations. In our case, a 26-yearold young woman was admitted to the hospital with complaints of severe chest pain. She had no risk factors for coronary heart disease but two of her sisters and one of her brothers had suffered sudden cardiac death. DNA samples obtained from peripheral blood were studied by polymerase chain reaction (PCR) and showed mutations in methylenetetrahydrofolate reductase (MTHFR) gene region C677T and heterozygous mutation in prothrombin gene region G20210A.
منابع مشابه
Myocardial Infarction in a Young Patient with Methylene Tetrahydrofolate Reductase (mthfr) Gene Mutation
Modifiable risk factors for CHD include high blood pressure, high blood cholesterol, smoking, obesity, physical inactivity, diabetes, and stress. When a patient presents with the typical features of CHD (like ours) but do not have the modifiable risk factors, genetic causes should be considered. A limited number of genetic variants are proven to be independent risk factors for thromboembolism. ...
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