Prokaryotic nucleotide excision repair: the UvrABC system.
نویسندگان
چکیده
Department of Pharmacological Sciences, State University of New York at Stony Brook, Stony Brook, New York 11794-5115, Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, and Rudolf Virchow Center for Experimental Biomedicine, Institute for Structural Biology, University of Würzburg, Versbacher Str. 9, 97078 Würzburg, Germany
منابع مشابه
How relevant is the Escherichia coli UvrABC model for excision repair in eukaryotes?
Knowledge about the DNA excision repair system is increasing rapidly. A detailed model for this process in Escherichia coli has emerged in which a lesion in the DNA is first recognized by the UvrA2B helicase complex. Subsequently, UvrC mediates incision on both sites of the DNA injury. Finally, the concerted action of helicase II (UvrD), polymerase and ligase takes care of removal of the damage...
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DNA damage recognition represents a long-standing problem in the field of protein-DNA interactions. This article reviews our current knowledge of how damage recognition is achieved in bacterial nucleotide excision repair through the concerted action of the UvrA, UvrB, and UvrC proteins.
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ورودعنوان ژورنال:
- Chemical reviews
دوره 106 2 شماره
صفحات -
تاریخ انتشار 2006