Enantioselective α-vinylation of aldehydes via the synergistic combination of copper and amine catalysis.
نویسندگان
چکیده
The enantioselective α-vinylation of aldehydes using vinyl iodonium triflate salts has been accomplished via the synergistic combination of copper and chiral amine catalysis. These mild catalytic conditions provide a direct route for the enantioselective construction of enolizable α-formyl vinylic stereocenters without racemization or olefin transposition. These high-value coupling adducts are readily converted into a variety of useful olefin synthons.
منابع مشابه
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ورودعنوان ژورنال:
- Journal of the American Chemical Society
دوره 134 22 شماره
صفحات -
تاریخ انتشار 2012