Quantitative Cytomorphology as an Additional Tool for Differentiation between Canine Cutaneous Sebaceous Adenomas and Sebaceous Carcinomas: a Preliminary Report
نویسنده
چکیده
Eight canine cutaneous sebaceous adenomas and eight canine cutaneous sebaceous carcinomas were analyzed by computer-assisted nuclear morphometry in Hemacolor stained cytological specimens. In each case, the nuclei of at least 100 neoplastic cells were measured, and the mean nuclear area (MNA), mean nuclear perimeter (MNP), minimum nuclear diameter (D min), maximum nuclear diameter (D max) and mean nuclear diameter (D mean) were calculated. The results indicated an increase of the mean values of investigated parameters from canine cutaneous sebaceous adenomas (MNA: 56.12 ± 3.55; MNP: 26.70 ± 1.06; D min: 7.62 ± 0.46; D max: 9.33 ± 0.47; D mean: 8.27 ± 0.26) to canine cutaneous sebaceous carcinomas (MNA: 80.91 ± 7.38; MNP: 32.04 ± 1.69; D min: 9.00 ± 0.35; D max: 11.16 ± 1.00; D mean: 9.97 ± 0.44). The statistical analysis revealed statistically significant differences between benign and malignant neoplastic cells (P < 0.01). The results indicated that the computerized morphometry could be used as an effective auxiliary tool for differential diagnosis between canine cutaneous sebaceous adenomas and carcinomas on cytologic smears.
منابع مشابه
Canine Skin Tumours with Adnexal Differentiation: Histopathology and Immunohistochemistry
Thirty nine canine adnexal tumours were histologically and immunohistochemically analysed. They were classified as trichoblastomas, trichoepitheliomas, sebaceous adenomas and epitheliomas, hepatoid gland adenomas and epitheliomas, and aporcine adenocarcinomas. Moreover, hepatoid gland angioadenoma and angioepithelioma were recognised. Studies of follicular tumours revealed coexpression of cytok...
متن کاملDistinction of benign sebaceous proliferations from sebaceous carcinomas by immunohistochemistry.
Sebaceous lesions, including sebaceous hyperplasia, sebaceomas, and sebaceous adenomas and carcinomas, are histologically distinctive adnexal proliferations with a spectrum of biological behavior ranging from benign to frankly malignant. The histologic distinction between sebaceous adenomas and carcinomas may be challenging, especially in cases showing atypical features and in small or partial ...
متن کاملLrig1 Expression in Human Sebaceous Gland Tumors
BACKGROUND Sebaceous glands contribute significantly to the barrier functions of the skin. However, little is known about their homeostasis and tumorigenesis. Recently, increased expression of stem cell marker Lrig1 has been reported in sebaceous carcinoma-like tumors of K14ΔNLef1 transgenic mice. In this study, we analyzed the Lrig1 expression in human sebaceous tumors. METHODS Twenty-eight ...
متن کاملMuir-Torre syndrome: case report and review of the literature.
Muir-Torre syndrome (MTS), a subtype of Lynch syndrome II, presents as at least one internal malignancy associated with at least one sebaceous skin tumor. This autosomal-dominant genetic disorder is thought to arise from microsatellite instability. Although not all patients with sebaceous tumors have MTS, even a single biopsy-proven sebaceous adenoma may warrant evaluation for MTS. We report th...
متن کاملCanine cutaneous neoplasms: prevalence and influence of age, sex and site on the presence and potential malignancy of cutaneous neoplasms in dogs from Zimbabwe.
Histopathological examination was performed on cutaneous biopsies from 900 dogs with skin lesions from Zimbabwe, collected from 1996 to 2000. Clinical data were collected from medical records. Sixty per cent (540/900) of the cases were tumours and 40% (360/900) were non-neoplastic inflammatory or degenerative diseases. Thirty different histological types of tumour were diagnosed. The prevalence...
متن کامل