Neurobiology of Disease Response of a Neuronal Model of Tuberous Sclerosis to Mammalian Target of Rapamycin (mTOR) Inhibitors: Effects on mTORC1 and Akt Signaling Lead to Improved Survival and Function
نویسندگان
چکیده
Lynsey Meikle,1 Kristen Pollizzi,1 Anna Egnor,1 Ioannis Kramvis,2 Heidi Lane,3 Mustafa Sahin,2 and David J. Kwiatkowski1 1Division of Translational Medicine, Department of Medicine, Brigham and Women’s Hospital and 2Department of Neurology, Children’s Hospital, Harvard Medical School, Boston, Massachusetts 02115, and 3Novartis Institutes for BioMedical Research, Oncology Basel, Novartis Pharma AG, CH-4002 Basel, Switzerland
منابع مشابه
Response of a neuronal model of tuberous sclerosis to mammalian target of rapamycin (mTOR) inhibitors: effects on mTORC1 and Akt signaling lead to improved survival and function.
Tuberous sclerosis (TSC) is a hamartoma syndrome attributable to mutations in either TSC1 or TSC2 in which brain involvement causes epilepsy, mental retardation, and autism. We have reported recently (Meikle et al., 2007) a mouse neuronal model of TSC in which Tsc1 is ablated in most neurons during cortical development. We have tested rapamycin and RAD001 [40-O-(2-hydroxyethyl)-rapamycin], both...
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