Immune surveillance of pre-cancerous senescent hepatocytes limits hepatocellular carcinoma development
نویسندگان
چکیده
Here we discuss a recently published study from our group on how a continuous CD4 T-cell dependent immune clearance of premalignant senescent cells, designated "senescence surveillance," restricts liver cancer development.
منابع مشابه
Registered report: Senescence surveillance of pre-malignant hepatocytes limits liver cancer development
The Kang et al. (2011), published in Nature in 2011. The experiments that will be replicated are those reported in Figures 3B, 3C, 3E, and 4A. In these experiments, Kang et al. (2011) demonstrate the phenomenon of oncogene-induced cellular senescence and immune-mediated clearance of senescent cells after intrahepatic injection of NRAS (Figures 2I, 3B, 3C, and 3E). Additionally, Kang et al. (201...
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